HIV treatment as prevention among people who inject drugs - a re-evaluation of the evidence.

ABSTRACT:

Background

Population-level associations between community measures of HIV viral load and HIV incidence have been interpreted as evidence for HIV anti-retroviral treatment (ART) as prevention among people who inject drugs (PWID). However, investigation of concurrent HCV and HIV incidence trends allows examination of alternative explanations for the fall in HIV incidence. We estimate the contribution of ART and reductions in injecting risk for reducing HIV incidence in Vancouver between 1996 and 2007.

Methods

A deterministic model of HIV and HCV transmission among PWID was calibrated to the baseline (1996) HIV and HCV epidemic among PWID in Vancouver. While incorporating parameter uncertainty, the model projected what levels of ART protection and decreases in injecting risk c

SUBMITTER: Fraser H 

PROVIDER: S-EPMC5837590 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature