Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats.

ABSTRACT:

Aim

The aim is to assess the effects of CDCs on heart structure, function, gene expression, and systemic parameters in aged rats. Diastolic dysfunction is characteristic of aged hearts. Cardiosphere-derived cell (CDC) therapy has exhibited several favourable effects on heart structure and function in humans and in preclinical models; however, the effects of CDCs on aging have not been evaluated.

Methods and results

We compared intra-cardiac injections of neonatal rat CDCs to vehicle (phosphate-buffered saline, PBS) in 21.8 ± 1.6 month-old rats (mean ± standard deviation; n = 23 total). Ten rats 4.1 ± 1.5 months of age comprised a young reference group. Blood, echocardiographic, haemodynamic and treadmill stress tests were performed at baseline in all animals, and 1 month aft

SUBMITTER: Grigorian-Shamagian L 

PROVIDER: S-EPMC5837602 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature