A brain-based pain facilitation mechanism contributes to painful diabetic polyneuropathy.

ABSTRACT: The descending pain modulatory system represents one of the oldest and most fundamentally important neurophysiological mechanisms relevant to pain. Extensive work in animals and humans has shown how a functional imbalance between the facilitatory and inhibitory components is linked to exacerbation and maintenance of persistent pain states. Forward translation of these findings into clinical populations is needed to verify the relevance of this imbalance. Diabetic polyneuropathy is one of the most common causes of chronic neuropathic pain; however, the reason why ∼25-30% of patients with diabetes develop pain is not known. The current study used a multimodal clinical neuroimaging approach to interrogate whether the sensory phenotype of painful diabetic polyneuropathy involves altered functi

SUBMITTER: Segerdahl AR 

PROVIDER: S-EPMC5837628 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature