Associations of parity-related reproductive histories with ER± and HER2± receptor-specific breast cancer aetiology.

ABSTRACT:

Background

Associations of reproductive history with breast cancer risk differ by oestrogen receptor (ER±) status and possibly by the joint expression of ER and the human epidermal growth factor receptor-2 (ER±/HER2±). However, large sample sizes are needed to establish ER-specific risks by HER2± expression.

Methods

We linked a cancer registry covering nearly 95% of the primary breast cancer diagnoses in Denmark with a research parity database to assess associations for parity, number of live births and age at first live birth (AFLB) with receptor-specific risk. Relative risks (RRs) for associations were estimated with Poisson regression models.

Results

With nearly 31 million women-years of follow-up, 45 786 Danish women aged 20-84 years developed invasive breast canc

SUBMITTER: Anderson WF 

PROVIDER: S-EPMC5837631 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature