Quantitative intravascular biological fluorescence-ultrasound imaging of coronary and peripheral arteries in vivo.

ABSTRACT:

Aims

(i) to evaluate a novel hybrid near-infrared fluorescence-intravascular ultrasound (NIRF-IVUS) system in coronary and peripheral swine arteries in vivo; (ii) to assess simultaneous quantitative biological and morphological aspects of arterial disease.

Methods and results

Two 9F/15MHz peripheral and 4.5F/40MHz coronary near-infrared fluorescence (NIRF)-IVUS catheters were engineered to enable accurate co-registrtation of biological and morphological readings simultaneously in vivo. A correction algorithm utilizing IVUS information was developed to account for the distance-related fluorescence attenuation due to through-blood imaging. Corrected NIRF (cNIRF)-IVUS was applied for in vivo imaging of angioplasty-induced vascular injury in swine peripheral arteries and experim

SUBMITTER: Bozhko D 

PROVIDER: S-EPMC5837649 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature