Serum uric acid, protein intake and mortality in hemodialysis patients.

ABSTRACT:

Background

The association between serum uric acid (SUA) and mortality has been conflicting among studies using hemodialysis (HD) patients. Given the close link between purine and protein in foods, we hypothesized that normalized protein catabolic rate (nPCR), a dietary protein intake surrogate, modifies the SUA-mortality association in the HD population.

Methods

We identified 4298 patients who initiated HD and had one or more SUA measurement in a contemporary cohort of HD patients over 5 years (1 January 2007-31 December 2011), and examined survival probability according to the first uric acid measurement, adjusting for dialysis vintage, case-mix and malnutrition-inflammation complex-related variables.

Results

Mean SUA concentration was 6.6 ± 1.8 mg/dL. There was a c

SUBMITTER: Park C 

PROVIDER: S-EPMC5837687 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature