Metabolic profiles of triple-negative and luminal A breast cancer subtypes in African-American identify key metabolic differences.

ABSTRACT: Breast cancer, a heterogeneous disease with variable pathophysiology and biology, is classified into four major subtypes. While hormonal- and antibody-targeted therapies are effective in the patients with luminal and HER-2 subtypes, the patients with triple-negative breast cancer (TNBC) subtype do not benefit from these therapies. The incidence rates of TNBC subtype are higher in African-American women, and the evidence indicates that these women have worse prognosis compared to women of European descent. The reasons for this disparity remain unclear but are often attributed to TNBC biology. In this study, we performed metabolic analysis of breast tissues to identify how TNBC differs from luminal A breast cancer (LABC) subtypes within the African-American and Caucasian breast cancer patien

SUBMITTER: Tayyari F 

PROVIDER: S-EPMC5837744 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature