Pooled analysis of active cigarette smoking and invasive breast cancer risk in 14 cohort studies.

ABSTRACT:

Background

The 2014 US Surgeon General's report noted research gaps necessary to determine a causal relationship between active cigarette smoking and invasive breast cancer risk, including the role of alcohol consumption, timing of exposure, modification by menopausal status and heterogeneity by oestrogen receptor (ER) status.

Methods

To address these issues, we pooled data from 14 cohort studies contributing 934 681 participants (36 060 invasive breast cancer cases). Cox proportional hazard regression models were used to calculate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Smoking duration before first birth was positively associated with risk ( P -value for trend = 2 × 10 -7 ) with the highest HR for initiation >10 years b

SUBMITTER: Gaudet MM 

PROVIDER: S-EPMC5837778 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature