Angiogenic gene therapy in cardiovascular diseases: dream or vision?

ABSTRACT: Chronic cardiovascular diseases are significant health problems. Although current treatment strategies have tremendously improved disease management, up to 30% of these patients cannot be successfully treated with current treatment approaches and new treatment strategies are clearly needed. Gene therapy and therapeutic vascular growth may provide a new treatment option for these patients. Several growth factors, like vascular endothelial growth factors, fibroblast growth factors and hepatocyte growth factor have been tested in clinical trials. However, apart from demonstration of increased vascularity, very few results with clinical significance have been obtained. Problems with gene transfer efficiency, short duration of transgene expression, selection of endpoints, and suboptimal patient

SUBMITTER: Yla-Herttuala S 

PROVIDER: S-EPMC5837788 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature