Gender and Pathology-Specific Effect of Apolipoprotein E Genotype on Psychosis in Alzheimer's Disease.

ABSTRACT:

Background

Symptoms of psychosis is one of the common clinical manifestations of Alzheimer's disease (AD). However, the pathophysiology behind psychosis is unknown.

Objective

The aim of the present study was to explore the relationship between Apolipoprotein E (APOE) genotype, Lewy body pathology, and psychosis in AD.

Method

The data was obtained from the National Alzheimer's disease Coordinating Centre (NACC), using the Uniform Data Set and the Neuropathology Data Set. Subjects with frequent neuritic plaque on CERAD, and Braak Stage of V or VI, corresponding to high probability of AD based on the NIA-AA Regan criteria were included in the analysis.

Results

Subjects with two copies of ε4 alleles were significantly more likely to develop psychosis, both delusion

SUBMITTER: Kim J 

PROVIDER: S-EPMC5837801 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature