PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache.

ABSTRACT: The interaction between sleep and primary headaches has gained considerable interest due to their strong, bidirectional, clinical relationship. Several primary headaches demonstrate either a circadian/circannual rhythmicity in attack onset or are directly associated with sleep itself. Migraine and cluster headache both show distinct attack patterns and while the underlying mechanisms of this circadian variation in attack onset remain to be fully explored, recent evidence points to clear physiological, anatomical and genetic points of convergence. The hypothalamus has emerged as a key brain area in several headache disorders including migraine and cluster headache. It is involved in homeostatic regulation, including pain processing and sleep regulation, enabling appropriate physiological re

SUBMITTER: Holland PR 

PROVIDER: S-EPMC5838029 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature