Cancer-associated fibroblasts induce antigen-specific deletion of CD8 ⁺ T Cells to protect tumour cells.

ABSTRACT: Tumours have developed strategies to interfere with most steps required for anti-tumour immune responses. Although many populations contribute to anti-tumour responses, tumour-infiltrating cytotoxic T cells dominate, hence, many suppressive strategies act to inhibit these. Tumour-associated T cells are frequently restricted to stromal zones rather than tumour islands, raising the possibility that the tumour microenvironment, where crosstalk between malignant and "normal" stromal cells exists, may be critical for T cell suppression. We provide evidence of direct interactions between stroma and T cells driving suppression, showing that cancer-associated fibroblasts (CAFs) sample, process and cross-present antigen, killing CD8⁺ T cells in an antigen-specific, antigen-dependent mann

SUBMITTER: Lakins MA 

PROVIDER: S-EPMC5838096 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature