Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition.

ABSTRACT: Candidate pro-cognitive drugs for schizophrenia targeting several neurochemical systems have consistently failed to demonstrate robust efficacy. It remains untested whether concurrent antipsychotic medications exert pharmacodynamic interactions that mitigate pro-cognitive action in patients. We used functional MRI (fMRI) in a randomized, double-blind, placebo-controlled within-subject crossover test of single-dose modafinil effects in 27 medicated schizophrenia patients, interrogating brainstem regions where catecholamine systems arise to innervate the cortex, to link cellular and systems-level models of cognitive control. Modafinil effects were evaluated both within this patient group and compared to a healthy subject group. Modafinil modulated activity in the locus coeruleus (LC) and ven

SUBMITTER: Minzenberg MJ 

PROVIDER: S-EPMC5838154 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature