Single Nucleotide Polymorphism (A870G) of the CCND1 gene: association with colorectal cancer susceptibility.

ABSTRACT:

Aim

The aim of this study is to demonstrate the role of CCND1 gene polymorphism, A870G, in susceptibility to sporadic colorectal cancer in Iranian population.

Background

It has been distinguished that CCND1 gene is one of the main genes in Wnt signaling pathway which involves in generating colorectal cancer. Nonetheless, there is no consistent result in terms of association between the genetic variations of this gene and colorectal cancer risk.

Methods

We designed a case-control study consisting of 100 subjects with colorectal cancer (CRC) and 100 healthy controls to investigate the effect of A870G polymorphism on CRC susceptibility in an Iranian population. Genotype determination was performed by PCR-RFLP method.

Results

The frequency of GG, AG a

SUBMITTER: Montazer Haghighi M 

PROVIDER: S-EPMC5838181 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature