Protein interaction mapping interpretation of none alcoholic fatty liver disease model of rats after fat diet feeding.

ABSTRACT:

Aim

This study investigates the effect of fat diet on gene expression profile in rat liver via protein-protein interaction mapping analysis.

Background

Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition of liver in the world. This progressive metabolic disease is representative with fat accumulation in the patients' liver that can led to advance stages, namely, cirrhosis and eventually cancer.

Methods

Differentially expressed genes of NAFLD rat liver after 2, 4 and 6 weeks fat diet feeding were analyzed via GEO2R and protein-protein interaction network by Cytoscape v3.6.0. and the related plug-ins. The important genes were assigned based on degree and betweenness centrality analysis and enriched using ClueGO+CluePedia Plug-in.

Results

GAPDH, PRDM

SUBMITTER: Abdollahi H 

PROVIDER: S-EPMC5838194 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature