Lonoctocog Alfa: A Review in Haemophilia A.

ABSTRACT: Lonoctocog alfa (rVIII-SingleChain; Afstyla^®) is a novel single-chain recombinant factor VIII (FVIII) molecule, with a truncated B-domain and the heavy and light chains covalently linked to form a stable and homogenous drug that binds with high affinity to von Willebrand factor (VWF). Intravenous lonoctocog alfa is approved for the prophylaxis and treatment of bleeding in patients with haemophilia A in several countries worldwide. In two pivotal, multicentre trials, lonoctocog alfa was effective in the treatment of bleeding episodes and as prophylaxis, including for perioperative management in adults, adolescents and children. In terms of haemostatic efficacy in controlling bleeding episodes, overall treatment and investigator-assessed success rates were high across all age grou

SUBMITTER: Al-Salama ZT 

PROVIDER: S-EPMC5838207 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature