Deoxynivalenol- and zearalenone-contaminated feeds alter gene expression profiles in the livers of piglets.

ABSTRACT:

Objective

The Fusarium mycotoxins of deoxynivalenol (DON) and zerolenone (ZEN) cause health hazards for both humans and farm animals. Therefore, the main intention of this study was to reveal DON and ZEN effects on the mRNA expression of pro-inflammatory cytokines and other immune related genes in the liver of piglets.

Methods

In the present study, 15 six-week-old piglets were randomly assigned to the following three different dietary treatments for 4 weeks: control diet, diet containing 8 mg DON/kg feed, and diet containing 0.8 mg ZEN/kg feed. After 4 weeks, liver samples were collected and sequenced using RNA-Seq to investigate the effects of the mycotoxins on genes and gene networks associated with the immune systems of the piglets.

Results

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SUBMITTER: Reddy KE 

PROVIDER: S-EPMC5838333 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature