The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction.

ABSTRACT: A variety of genetic approaches, including twin studies, linkage studies, and candidate gene studies, has established a firm genetic basis for addiction. However, there has been difficulty identifying the precise genes that underlie addiction liability using these approaches. This situation became especially clear in genome-wide association studies (GWAS) of addiction. Moreover, the results of GWAS brought into clarity many of the shortcomings of those early genetic approaches. GWAS studies stripped away those preconceived notions, examining genes that would not previously have been considered in the study of addiction, consequently creating a shift in our understanding. Most importantly, those studies implicated a class of genes that had not previously been considered in the study of addi

SUBMITTER: Muskiewicz DE 

PROVIDER: S-EPMC5838467 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature