Stimulating neural plasticity with real-time fMRI neurofeedback in Huntington's disease: A proof of concept study.

ABSTRACT: Novel methods that stimulate neuroplasticity are increasingly being studied to treat neurological and psychiatric conditions. We sought to determine whether real-time fMRI neurofeedback training is feasible in Huntington's disease (HD), and assess any factors that contribute to its effectiveness. In this proof-of-concept study, we used this technique to train 10 patients with HD to volitionally regulate the activity of their supplementary motor area (SMA). We collected detailed behavioral and neuroimaging data before and after training to examine changes of brain function and structure, and cognitive and motor performance. We found that patients overall learned to increase activity of the target region during training with variable effects on cognitive and motor behavior. Improved cognitiv

SUBMITTER: Papoutsi M 

PROVIDER: S-EPMC5838530 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature