Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital Malformations: A Cohort Study From the International Pregnancy Safety Study Consortium.

ABSTRACT:

Importance

Given the rapidly increasing use of stimulant medications during pregnancy and among women of reproductive age who may become pregnant inadvertently, there is a need to better understand their safety.

Objective

To examine the risk of congenital malformations associated with intrauterine exposure to stimulants.

Design, setting, and participants

Cohort study of the Medicaid-insured population in the United States nested in the 2000-2013 US Medicaid Analytic eXtract, with follow-up of safety signals detected in the Medicaid Analytic eXtract data using the Nordic Health registries (2003-2013) (Denmark, Finland, Iceland, Norway, and Sweden). A total of 1 813 894 publicly insured pregnancies in the United States and 2 560 069 singleton pregnancies in the 5 Nordic

SUBMITTER: Huybrechts KF 

PROVIDER: S-EPMC5838573 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature