Association of Functional Loss With the Biomechanical Response of the Optic Nerve Head to Acute Transient Intraocular Pressure Elevations.

ABSTRACT:

Importance

The acute biomechanical response of the optic nerve head (ONH) to intraocular pressure (IOP) elevations may serve as a biomarker for the development and progression of glaucoma.

Objective

To evaluate the association between visual field loss and the biomechanical response of the ONH to acute transient IOP elevations.

Design, setting, and participants

In this observational study, 91 Chinese patients (23 with primary open-angle glaucoma [POAG], 45 with primary angle-closure glaucoma, and 23 without glaucoma) were recruited from September 3, 2014, through February 2, 2017. Optical coherence tomography scans of the ONH were acquired at baseline and at 2 sequential IOP elevations (0.64 N and then 0.90 N, by applying forces to the anterior sclera using an ophthal

SUBMITTER: Tun TA 

PROVIDER: S-EPMC5838605 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature