Effect of Different Doses of Galcanezumab vs Placebo for Episodic Migraine Prevention: A Randomized Clinical Trial.

ABSTRACT:

Importance

Galcanezumab (LY2951742), a monoclonal antibody against calcitonin gene-related peptide (CGRP), is one of a novel class of new medicines for migraine prevention.

Objective

To assess whether at least 1 dose of galcanezumab was superior to placebo for episodic migraine prevention.

Design, setting, and participants

A randomized clinical trial was conducted in the United States (July 7, 2014, to August 19, 2015) in clinics of 37 licensed physicians with a specialty including, but not limited to, psychiatry, neurology, internal medicine, and primary care. Subcutaneous injections of galcanezumab, 5, 50, 120, or 300 mg, or placebo were given monthly during the 3-month treatment period. A total of 936 patients were assessed; 526 did not meet study entry or baseline

SUBMITTER: Skljarevski V 

PROVIDER: S-EPMC5838630 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature