Plasma Nervonic Acid Is a Potential Biomarker for Major Depressive Disorder: A Pilot Study.

ABSTRACT:

Background

Diagnostic biomarkers of major depressive disorder, bipolar disorder, and schizophrenia are urgently needed, because none are currently available.

Methods

We performed a comprehensive metabolome analysis of plasma samples from drug-free patients with major depressive disorder (n=9), bipolar disorder (n=6), schizophrenia (n=17), and matched healthy controls (n=19) (cohort 1) using liquid chromatography time-of-flight mass spectrometry. A significant effect of diagnosis was found for 2 metabolites: nervonic acid and cortisone, with nervonic acid being the most significantly altered. The reproducibility of the results and effects of psychotropic medication on nervonic acid were verified in cohort 2, an independent sample set of medicated patients [major depressive di

SUBMITTER: Kageyama Y 

PROVIDER: S-EPMC5838832 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature