Mammalian genomic regulatory regions predicted by utilizing human genomics, transcriptomics, and epigenetics data.

ABSTRACT: Genome sequences for hundreds of mammalian species are available, but an understanding of their genomic regulatory regions, which control gene expression, is only beginning. A comprehensive prediction of potential active regulatory regions is necessary to functionally study the roles of the majority of genomic variants in evolution, domestication, and animal production. We developed a computational method to predict regulatory DNA sequences (promoters, enhancers, and transcription factor binding sites) in production animals (cows and pigs) and extended its broad applicability to other mammals. The method utilizes human regulatory features identified from thousands of tissues, cell lines, and experimental assays to find homologous regions that are conserved in sequences and genome organizat

SUBMITTER: Nguyen QH 

PROVIDER: S-EPMC5838836 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature