The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study.

ABSTRACT:

Background

Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and cardiac parameters from a large-scale Korean CKD cohort.

Methods

We analyzed 2101 participants from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort who had been measured for serum klotho levels. Left ventricular hypertrophy evaluated by left ventricular mass index (LVMI) and arterial stiffness measured by brachial-to-ankle pulse wave velocity (baPWV) were explored as cardiovascular parameters.

Results

Patients were 53.6 ± 12.2 years old and

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC5838864 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature