Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is associated with significant mortality rates amongst hematopoietic stem cell transplant (HSCT) recipients, with less known about other immunocompromised patients.

Methods

Ten-year retrospective cohort study of immunocompromised patients presenting with RSV disease documented at University Hospitals of Lausanne and Geneva. Severe RSV-related outcomes referred to RSV documented respiratory conditions requiring hospital admission, presenting as lower respiratory tract infection (LRTI) or pneumonia. We used multivariable logistic regression to assess clinical and laboratory correlates of severe RSV disease.

Results

From 239 RSV-positive immunocompromised in and out-patients 175 were adults and 64 children of whom 111 (47.8%)

SUBMITTER: Chatzis O 

PROVIDER: S-EPMC5838875 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature