Dataset Information

Prevalence Rates of ADIPOQ Polymorphisms in Indian Population and a Comparison with Other Populations.

ABSTRACT:

Introduction

The adiponectin gene, ADIPOQ, encodes an adipocytokine, known as adiponectin hormone. This hormone is known to be associated with insulin sensitization, fat metabolism, immunity, and inflammatory response. Polymorphisms in ADIPOQ gene lower the adiponectin levels, increasing the risk for diabetes and cardiovascular diseases.

Aims

The study aimed to calculate the prevalence rates of ADIPOQ polymorphisms in Indian population and to compare those prevalence rates with that of other populations.

Subjects and methods

Microarray-based genotypic data of 14 ADIPOQ polymorphisms from 703 individuals of Indian origin were used.

Statistical analysis used

Frequency estimation, identity-by-descent, Hardy-Weinberg equilibrium, Chi-square test of significance were used for statistical analysis.

Results

Allelic and genotypic frequencies of ADIPOQ polymorphisms, Chi-square tests of significance for allelic and genotypic frequencies across various populations.

Conclusions

East Asians are very different from Indians in terms of allelic and genotypic frequencies of ADIPOQ polymorphisms. Europeans have similar genotypic and allelic patterns with Indians. Admixture Americans and Africans also showed significant differences with polymorphisms of the Indian population.

SUBMITTER: Pemmasani SK

PROVIDER: S-EPMC5838907 | biostudies-literature | 2018 Jan-Feb

REPOSITORIES: biostudies-literature

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Publications

Prevalence Rates of ADIPOQ Polymorphisms in Indian Population and a Comparison with Other Populations.

Pemmasani Sandhya Kiran SK Raman Rasika R Acharya Anuradha A

Indian journal of endocrinology and metabolism 20180101 1

<h4>Introduction</h4>The adiponectin gene, <i>ADIPOQ</i>, encodes an adipocytokine, known as adiponectin hormone. This hormone is known to be associated with insulin sensitization, fat metabolism, immunity, and inflammatory response. Polymorphisms in <i>ADIPOQ</i> gene lower the adiponectin levels, increasing the risk for diabetes and cardiovascular diseases.<h4>Aims</h4>The study aimed to calculate the prevalence rates of ADIPOQ polymorphisms in Indian population and to compare those prevalence ...[more]

PMID: 29535934

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Project description:We have examined the association of 14 tagging single nucleotide polymorphisms (tagSNPs) in peroxisome proliferator activated receptor-gamma transcripts 1 and 2 (PPARG1 and 2) and 5 tagSNPs in adiponectin (ADIPOQ) genes for their effect on type 2 diabetes mellitus (T2D) risk in Asian Indian Sikhs. A total of 554 T2D cases and 527 normoglycemic controls were examined for association with T2D and other subphenotypes of T2D. With the exception of a strong association of PPARG2/Pro12Ala with T2D (odds ratio, 0.13; 95% confidence interval, 0.03-0.56; P = .0007), no other tagSNP in the PPARG locus revealed any significant association with T2D in this population. Similarly, none of the tagSNPs in the ADIPOQ gene was associated with T2D susceptibility in single-site analysis. However, haplotype analysis provided strong evidence of association of these loci with T2D. Three-site haplotype analysis in the PPARG locus using the 2 marginally associated SNPs (P/rs11715073 and P/rs3892175) in combination with Pro12 Ala (P/rs1801282) revealed a strong association of 1 "risk" (CGC) (P = .003, permutation P = .015) and 1 "protective" (CAC) (P = .001, permutation P = .005) haplotype associated with T2D. However, the major effect still appears to be driven by Pro12Ala, as the association of these haplotypes did not remain significant when analyzed conditional upon Pro12Ala (P = .262). In addition, 2-site haplotype analysis in the ADIPOQ locus using only 2 marginally associated SNPs (AD/rs182052 and AD/rs7649121) revealed a significant protective association of the GA haplotype with T2D (P = .009, permutation P = .026). Multiple linear regression analysis also revealed significant association of an ADIPOQ variant (AD/rs12495941) with total body weight (P = .010), waist (P = .024), and hip (P = .021), although these associations were not significant after adjusting for multiple testing. Our new findings strongly suggest that the genetic variation in PPARG and ADIPOQ loci could contribute to the risk for the development of T2D in Indian Sikhs. Identification of causal SNPs in these important biological and positional candidate genes would help determine the true physiologic significance of these loci in T2D and obesity.

Dataset Information

Prevalence Rates of ADIPOQ Polymorphisms in Indian Population and a Comparison with Other Populations.

Introduction

Aims

Subjects and methods

Statistical analysis used

Results

Conclusions

Publications

Prevalence Rates of ADIPOQ Polymorphisms in Indian Population and a Comparison with Other Populations.

Similar Datasets

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