The left frontal cortex supports reserve in aging by enhancing functional network efficiency.

ABSTRACT: BACKGROUND:Recent evidence derived from functional magnetic resonance imaging (fMRI) studies suggests that functional hubs (i.e., highly connected brain regions) are important for mental health. We found recently that global connectivity of a hub in the left frontal cortex (LFC connectivity) is associated with relatively preserved memory abilities and higher levels of protective factors (education, IQ) in normal aging and Alzheimer's disease. These results suggest that LFC connectivity supports reserve capacity, alleviating memory decline. An open question, however, is why LFC connectivity is beneficial and supports memory function in the face of neurodegeneration. We hypothesized that higher LFC connectivity is associated with enhanced efficiency in connected major networks involved in ep

SUBMITTER: Franzmeier N 

PROVIDER: S-EPMC5838935 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature