A missense mutation in MYH1 is associated with susceptibility to immune-mediated myositis in Quarter Horses.

ABSTRACT:

Background

The cause of immune-mediated myositis (IMM), characterized by recurrent, rapid-onset muscle atrophy in Quarter Horses (QH), is unknown. The histopathologic hallmark of IMM is lymphocytic infiltration of myofibers. The purpose of this study was to identify putative functional variants associated with equine IMM.

Methods

A genome-wide association (GWA) study was performed on 36 IMM QHs and 54 breed matched unaffected QHs from the same environment using the Equine SNP50 and SNP70 genotyping arrays.

Results

A mixed model analysis identified nine SNPs within a ~ 2.87 Mb region on chr11 that were significantly (P_unadjusted < 1.4 × 10^- 6) associated with the IMM phenotype. Associated haplotypes within this region encompassed 38 annotated gene

SUBMITTER: Finno CJ 

PROVIDER: S-EPMC5838957 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature