Characterization of the human RFX transcription factor family by regulatory and target gene analysis.

ABSTRACT:

Background

Evolutionarily conserved RFX transcription factors (TFs) regulate their target genes through a DNA sequence motif called the X-box. Thereby they regulate cellular specialization and terminal differentiation. Here, we provide a comprehensive analysis of all the eight human RFX genes (RFX1-8), their spatial and temporal expression profiles, potential upstream regulators and target genes.

Results

We extracted all known human RFX1-8 gene expression profiles from the FANTOM5 database derived from transcription start site (TSS) activity as captured by Cap Analysis of Gene Expression (CAGE) technology. RFX genes are broadly (RFX1-3, RFX5, RFX7) and specifically (RFX4, RFX6) expressed in different cell types, with high expression in four organ systems: immune system, gast

SUBMITTER: Sugiaman-Trapman D 

PROVIDER: S-EPMC5838959 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature