Bayesian analysis of genome-wide inflammatory bowel disease data sets reveals new risk loci.

ABSTRACT: Genome-wide association studies (GWAS) have identified and validated 200 risk loci for inflammatory bowel disease (IBD) to date, including risk loci for both Crohn's disease and ulcerative colitis. Previously studies mainly used single SNP testing methods and only reported the most significant association within each locus. Advanced methods are needed to detect additional joint effects of multiple SNPs and fine map causal variants in presence of strong linkage disequilibrium. In this study, we applied a powerful Bayesian method to analyze an existing Immunochip data sets for IBD from the international inflammatory bowel disease genetics consortium. The method jointly tested single and set-based SNPs in a unified framework and filtered indirect associations due to linkage disequilibrium, th

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5838995 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature