Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis.

ABSTRACT:

Background

Immuno-oncology and cancer immunotherapies are areas of intense research. The numbers and locations of CD8+ tumor-infiltrating lymphocytes (TILs) are important measures of the immune response to cancer with prognostic, pharmacodynamic, and predictive potential. We describe the development, validation, and application of advanced image analysis methods to characterize multiple immunohistochemistry-derived CD8 parameters in clinical and nonclinical tumor tissues.

Methods

Commercial resection tumors from nine cancer types, and paired screening/on-drug biopsies of non-small-cell lung carcinoma (NSCLC) patients enrolled in a phase 1/2 clinical trial investigating the PD-L1 antibody therapy durvalumab (NCT01693562), were immunostained for CD8. Additional NCT01693562 sam

SUBMITTER: Steele KE 

PROVIDER: S-EPMC5839005 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature