Proteomic characterization of high-density lipoprotein particles in patients with non-alcoholic fatty liver disease.

ABSTRACT:

Background

Metabolic diseases such as obesity and diabetes are associated with changes in high-density lipoprotein (HDL) particles, including changes in particle size and protein composition, often resulting in abnormal function. Recent studies suggested that patients with non-alcoholic fatty liver disease (NAFLD), including individuals with non-alcoholic steatohepatitis (NASH), have smaller HDL particles when compared to individuals without liver pathologies. However, no studies have investigated potential changes in HDL particle protein composition in patients with NAFLD, in addition to changes related to obesity, to explore putative functional changes of HDL which may increase the risk of cardiovascular complications.

Methods

From a cohort of morbidly obese females who we

SUBMITTER: Rao PK 

PROVIDER: S-EPMC5839024 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature