Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors.

ABSTRACT: Single-nucleotide polymorphisms (SNPs) contributing to interactions between regulatory elements that modulate gene transcription may explain some of the uncharacterized variation for complex traits. We explored this hypothesis among 856 adult survivors of pediatric cancer exposed to curative treatments that adversely affect bone mineral density (BMD). To restrict our search to interactions among SNPs in regulatory elements, our analysis considered 75523 SNPs mapped to putative promoter or enhancer regions. In anticipation that power to detect higher order epistasis would be low using an exhaustive search and a Bonferroni-corrected threshold for genome-wide significance (e.g., P < 5.6 × 10^-14), a novel non-exhaustive statistical algorithm was implemented to detect chromosome-wide

SUBMITTER: Im C 

PROVIDER: S-EPMC5839052 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature