The Influence of Genetic Variability on the Risk of Developing Malignant Mesothelioma.

ABSTRACT:

Background

Malignant mesothelioma is a rare cancer with poor outcome, associated with asbestos exposure. Reactive oxygen species may play an important role in the mechanism of carcinogenesis; therefore, genetic variability in antioxidative defence may modify an individual's susceptibility to this cancer. This study investigated the influence of functional polymorphisms of NQO1, CAT, SOD2 and hOGG1 genes, gene-gene interactions and gene-environment interactions on malignant mesothelioma risk.

Patients and methods

In total, 150 cases with malignant mesothelioma and 122 controls with no asbestos-related disease were genotyped for NQO1, CAT, SOD2 and hOGG1 polymorphisms.

Results

The risk of malignant mesothelioma inc

SUBMITTER: Franko A 

PROVIDER: S-EPMC5839088 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature