Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians.

ABSTRACT: RATIONALE:The beneficial effects of moderate alcohol may differ in aging men versus women. OBJECTIVES:Cognitive and functional decline and neuropathology were investigated in a cohort of aging men and women with diverse alcohol histories. METHODS:Non-demented (Clinical Dementia Rating (CDR) of ≤ 0.5 and a Mini-Mental State Examination (MMSE) score of > 24), autonomously living participants were tracked in longitudinal aging studies to examine self-report and objective tests of rates of decline in a cohort (n = 486) of octogenarians. Neurofibrillary tangles (NFTs; Braak stage) and neuritic plaques (NPs) were staged at autopsy in a subset of participants (n = 149) using current standard neuropathologic diagnostic criteria. RESULTS:Moderate drinking men had an attenuated rate of decline compa

SUBMITTER: Wardzala C 

PROVIDER: S-EPMC5839119 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature