Discontinuation of simvastatin leads to a rebound phenomenon and results in immediate peri-implant bone loss.

ABSTRACT: Although administration of simvastatin has been reported to promote bone formation, the effect of short-term simvastatin administration is not well known. Following implant installation, 10-week-old male Wistar rats (n = 24) were divided into two groups randomly. The experimental group received 10 mg/kg of simvastatin daily for seven days. Then simvastatin administration was discontinued, and the animals were observed up to 28 days. Animals in the control group underwent the same procedure but received saline instead of simvastatin. All animals were analyzed by micro-computed tomography. Samples at days 14 and 21 were subjected to histological analyses. After seven days of simvastatin administration, more new bone formation around the implant was observed in the simvastatin group co

SUBMITTER: Li X 

PROVIDER: S-EPMC5839186 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature