Adverse effects of paternal chemotherapy exposure on the progeny brain: intergenerational chemobrain.

ABSTRACT: Recent advances in cancer treatments have led to significant increases in cure rates. Most cancer patients are treated with various cytotoxic chemotherapy regimens. These treatment modalities are mutagenic and genotoxic and cause a wide array of late-occurring health problems, and even exert a deleterious influence on future offspring. The adverse effects from exposed parents on offspring are referred to as transgenerational effects, and currently little is known about chemotherapy-induced transgenerational effects. Furthermore, transgenerational effects have not been studied in the brains of progeny of exposed parents. In this study, we analyzed the existence and molecular nature of transgenerational effects in the brains of progeny of animals exposed to three common chemotherapy agents:

SUBMITTER: Kovalchuk A 

PROVIDER: S-EPMC5839372 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature