Neovascular PSMA expression is a common feature in malignant neoplasms of the thyroid.

ABSTRACT:

Aim

PSMA (prostate-specific membrane antigen) is physiologically expressed in normal prostate tissue and over expressed in prostate cancer cells, therefore constituting a potential target for antibody-based radioligand therapy. Very recent imaging findings reported PSMA-PET/CT uptake in various thyroid lesions. We were therefore encouraged to systematically analyse PSMA expression in different benign and malignant thyroid lesions.

Methods

Immunohistochemistry was used to detect PSMA expression in 101 thyroid lesions, while neovasculature was identified by CD34 immunostaining.

Results

PSMA expression in the neovasculature was significantly more frequent in malignant tumors (36/63; 57.1%) compared to benign diseases (5/38; 13.2%; p = 0.0001). In addition, PSMA ex

SUBMITTER: Heitkotter B 

PROVIDER: S-EPMC5839407 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature