Comprehensive Analysis of Non-Synonymous Natural Variants of G Protein-Coupled Receptors.

ABSTRACT: G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are the most commonly used therapeutic target. It has been suggested that GPCRs undergo massive genetic variations such as genetic polymorphisms and DNA insertions or deletions. Among these genetic variations, non-synonymous natural variations change the amino acid sequence and could thus alter GPCR functions such as expression, localization, signaling, and ligand binding, which may be involved in disease development and altered responses to GPCR-targeting drugs. Despite the clinical importance of GPCRs, studies on the genotype-phenotype relationship of GPCR natural variants have b

SUBMITTER: Kim HR 

PROVIDER: S-EPMC5839487 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature