Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study.

ABSTRACT: Current guideline-recommended screening for pulmonary hypertension in patients with systemic sclerosis has not been evaluated in systemic lupus erythematosus (SLE), which is disproportionately prevalent in Asians. This multicentre, cross-sectional screening study aims to study the prevalence of pulmonary hypertension among SLE patients using these guidelines, and identify independent predictors and develop a prediction model for pulmonary hypertension in SLE patients. SLE patients from participating centres will undergo an echocardiography- and biomarker-based pulmonary hypertension screening procedure as in the DETECT study. Standard right heart catheterisation will be provided to patients with intermediate or high echocardiographic probability of pulmonary hypertension. Those with low ec

SUBMITTER: Huang D 

PROVIDER: S-EPMC5839606 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature