Genetic factors associated with iron storage in Australian blood donors.

ABSTRACT:

Background

Blood donors are at risk of developing iron deficiency and/or iron deficiency anaemia. This may affect their health and affect their eligibility to give subsequent donations. Investigating genetic factors that may predispose donors to high or low iron stores is of interest; this may assist with providing optimal management strategies for maintaining donor health. This study aimed to investigate whether the presence of selected single nucleotide polymorphisms (SNPs) affecting parameters of iron status were associated with ferritin levels in Australian donors.

Materials and methods

Samples (n=800) were collected from non-first-time blood donors in Queensland. Plasma ferritin levels were quantified and the genotypes for ten SNPs, identified by a review of relevant li

SUBMITTER: Ji Y 

PROVIDER: S-EPMC5839608 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature