Prevalence of CYP2C19 Genetic Polymorphism among Normal People and Patients with Hepatic Diseases.

ABSTRACT:

Background

Patients with hepatic diseases are treated with numerous drugs metabolized by cytochrome P450.

Objective

To evaluate the frequencies of CYP2C19 variant alleles (*2, *3, and *17), genotypes, and phenotypes, and the relationship between the frequency of these alleles and the underlying hepatic diseases among patients with advanced liver diseases who were candidates for liver transplantation.

Methods

The Study was conducted on 120 patients suffering from various hepatic disorders, candidates for liver transplantation, and 52 healthy volunteers. DNA was extracted from blood samples and analyzed by TaqMan SNP genotyping assay. The CYP2C19 genotypes were classified into poor, extensive, intermediate, and ultra-rapid metabolizer phenotypes.

Results

Viral he

SUBMITTER: Hashemizadeh Z 

PROVIDER: S-EPMC5839627 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature