A scored human protein-protein interaction network to catalyze genomic interpretation.

ABSTRACT: Genome-scale human protein-protein interaction networks are critical to understanding cell biology and interpreting genomic data, but challenging to produce experimentally. Through data integration and quality control, we provide a scored human protein-protein interaction network (InWeb_InBioMap, or InWeb_IM) with severalfold more interactions (>500,000) and better functional biological relevance than comparable resources. We illustrate that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism.

SUBMITTER: Li T 

PROVIDER: S-EPMC5839635 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature