Ontology highlight
ABSTRACT:
SUBMITTER: Balbinot C
PROVIDER: S-EPMC5839756 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20180208 3
Developmental genes contribute to cancer, as reported for the homeobox gene <i>Cdx2</i> playing a tumor suppressor role in the gut. In this study, we show that human colon cancers exhibiting the highest reduction in <i>CDX2</i> expression belong to the serrated subtype with the worst evolution. In mice, mosaic knockout of <i>Cdx2</i> in the adult intestinal epithelium induces the formation of imperfect gastric-type metaplastic lesions. The metaplastic knockout cells do not spontaneously become t ...[more]