Administration of increasing doses of gonadotropin-releasing hormone in men with spinal cord injury to investigate dysfunction of the hypothalamic-pituitary-gonadal axis.

ABSTRACT:

Study design

Prospective.

Objectives

To determine the optimum gonadotropin-releasing hormone (GnRH) dose to identify dysfunction of the hypothalamic-pituitary-gonadal axis in men with spinal cord injury (SCI).

Setting

Metropolitan Area Hospitals, New York and New Jersey, USA.

Methods

SCI men (16 hypogonadal (HG = serum testosterone <12.1 nmol/l) and 14 eugonadal (EG)) and able-bodied (AB) men (27 HG and 11 EG) were studied. GnRH (10, 50, and 100 μg) was randomly administered intravenously on three separate visits. Blood samples were collected post-GnRH for serum-luteinizing hormone (LH) and follicular-stimulating hormone (FSH).

Results

HG and EG men had a similar proportion of clinically acceptable gonadotropin responses to all three GnRH doses. The incr

SUBMITTER: Bauman WA 

PROVIDER: S-EPMC5839914 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature