Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?

ABSTRACT:

Background

Numerous studies have established botulinum toxin (BoNT) to be safe and effective for the treatment of cervical dystonia (CD). Despite its well-documented efficacy, there has been growing awareness that a significant proportion of CD patients discontinue therapy. The reasons for discontinuation are only partly understood.

Methods

This summary describes longitudinal studies that provided information regarding the proportions of patients discontinuing BoNT therapy, and the reasons for discontinuing therapy. The data come predominantly from un-blinded long-term follow-up studies, registry studies, and patient-based surveys.

Results

All types of longitudinal studies provide strong evidence that BoNT is both safe and effective in the treatment of CD for many yea

SUBMITTER: Jinnah HA 

PROVIDER: S-EPMC5839920 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature