Genomics of Cardiovascular Measures of Autonomic Tone.

ABSTRACT: The autonomic nervous system exerts broad control over the involuntary functions of the human body through complex equilibrium between sympathetic and parasympathetic tone. Imbalance in this equilibrium is associated with a multitude of cardiovascular outcomes, including mortality. The cardiovascular static state of this equilibrium can be quantified using physiological parameters such as heart rate (HR), blood pressure, and by spectral analysis of HR variability. Here, we review the current state of knowledge of the genetic background of cardiovascular measurements of autonomic tone. For most parameters of autonomic tone, a large portion of variability is explained by genetic heritability. Many of the static parameters of autonomic tone have also been studied through candidate-gene approa

SUBMITTER: Sigurdsson MI 

PROVIDER: S-EPMC5839974 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature