Ontology highlight
ABSTRACT:
SUBMITTER: Akkaya M
PROVIDER: S-EPMC5839995 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nature immunology 20180223 3
Key events in T cell-dependent antibody responses, including affinity maturation, are dependent on the B cell's presentation of antigen to helper T cells at critical checkpoints in germinal-center formation in secondary lymphoid organs. Here we found that signaling via Toll-like receptor 9 (TLR9) blocked the ability of antigen-specific B cells to capture, process and present antigen and to activate antigen-specific helper T cells in vitro. In a mouse model in vivo and in a human clinical trial, ...[more]