Extracellular Matrix Modulation Is Driven by Experience-Dependent Plasticity During Stroke Recovery.

ABSTRACT: Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-stroke tissue reorganization is modulated by growth inhibitory molecules differentially expressed within the ischemic hemisphere, like chondroitin sulfate proteoglycans found in perineuronal nets (PNNs). PNNs in the neocortex predominantly enwrap parvalbumin-containing GABAergic (PV/GABA) neurons, important in sensori-information processing. Here, we investigate how extracellular matrix (ECM) proteases and their inhibitors may participate in the regulation of PNN integrity dur

SUBMITTER: Quattromani MJ 

PROVIDER: S-EPMC5840227 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature